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This is Scary!

Next new fad in quick weight loss products will contain PRDM16

Scientists from the Dana-Farber Cancer Institute have discovered that PRDM16, a protein derivative, can manipulate and control the development of fat cells.

PRDM16 regulates the creation of fat-burning, brown fat cells from immature muscle cells and was confirmed to be a “master regulator” of increased brown fat development. In a nutshell, PRDM16 controls a cell’s fate.

The human body consists of both brown and white fat cells. Brown fat cells burn fat and are classified as heat generators whereas white fat cells are responsible for storage, specifically energy. “Three ounces of brown fat can burn several hundred calories a day,” said Aaron Cypess, MD, PhD, of the Joslin Diabetes Center in Boston. So, the adage, what you don’t use, you will lose applies to everything except fat, since unused white fat cells, do not die, but multiply, creating a surplus. Dana-Farber’s Bruce Spiegelman, the senior researcher of the the study, said in Science Daily, “the finding confirms that PRDM16 is the ‘master regulator’ of brown fat development.

Possibility of transplanting PRDM16-equipped white fat cells into people…

Spiegelman’s group inserted PRDM16 genes into white fat precursors, which they implanted under the skin of mice. Satellite (peripheral) cells “gave birth” to brown fat cells when regulated by PRDM16, suggesting the possibility of transplanting PRDM16-equipped white fat cells into people who are at high risk of becoming obese. The PRDM16 trigger “is very powerful” said Spiegelman. “I think we now have very convincing evidence that PRDM16 can combat obesity,”  he said.

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